Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis.

ABSTRACT:

Background

Lymph node metastasis is a significant problem in breast cancer, and its underlying molecular mechanism is still unclear. The purpose of this study is to research the molecular mechanism and to explore the key RNAs and pathways that mediate lymph node metastasis in breast cancer.

Methods

GSE100453 and GSE38167 were downloaded from the Gene Expression Omnibus (GEO) database and 569 breast cancer statistics were also downloaded from the TCGA database. Differentially expressed miRNAs were calculated by using R software and GEO2R. Gene ontology and Enriched pathway analysis of target mRNAs were analyzed by using the Database for Database of Annotation Visualization and Integrated Discovery (DAVID) and R software. The protein-protein interaction (PPI) network was perfo

SUBMITTER: Gao G 

PROVIDER: S-EPMC7523764 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature