Protective effects of alpha stone on monosodium glutamate-induced uterine hyperplasia in female wistar rats.

ABSTRACT:

Background

Uterine leiomyomas (fibroids), a menace of the reproductive age, is characterized by proliferation of smooth muscle cells (hyperplasia) of the uterus. Alpha Stone Decoction is a poly-herbal formulation that is used for the shrinkage and prevention of uterine fibroids in folkore medicine.

Objective

We investigated the efficacy and safety of Alpha Stone Decoction (ASD), on monosodium glutamate (MSG) induced uterine hyperplasia.

Materials and methods

Twenty-eight mature virgin female rats were randomly divided into four study groups: A-control B- MSG (200 mg/kgbw), C- MSG + ASD (100 mg/kgbw) and D- ASD 100 mg/kgbw alone. The administration was carried out by as a single daily dose via intraperitoneal route for 14 days. Total protein, triglycerides, estradiol (

SUBMITTER: Oyebode OT 

PROVIDER: S-EPMC7527998 | biostudies-literature | 2020 Jul - Sep

REPOSITORIES: biostudies-literature