Prevalence of GBA p.K198E mutation in Colombian and Hispanic populations.

ABSTRACT: We aimed to replicate a recent study that found a high frequency of the GBA p.K198E mutant in Colombian patients with PD. We identified the p.K198E substitution at a lower frequency in our cohort of Colombians with PD (2.1%), and this was not significantly different than controls (1.7%, P = 0.86) emphasizing the need for larger genetic studies in Latin America.

SUBMITTER: Tipton PW 

PROVIDER: S-EPMC7528207 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature