Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization.

ABSTRACT:

Background

The causal effects of plasma lipid concentrations and the risk of primary open angle glaucoma (POAG) are still unclear. Thus, the purpose of this study was to identify, applying a two-sample Mendelian randomization (MR) analysis, whether plasma lipid concentrations are causally associated with the risk of POAG.

Methods

Two-sample MR analysis of data from a genome-wide association study (GWAS) was performed to investigate the causal role of plasma lipid levels and POAG. A total of 185 independent single-nucleotide polymorphisms (SNPs) associated with plasma lipid levels were selected as instrumental variables (IVs). The SNPs were obtained from a meta-analysis of GWAS based on 188,577 European-ancestry individuals for MR analyses. Association with POAG for the SNPs

SUBMITTER: Xu M 

PROVIDER: S-EPMC7532556 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature