Antiviral effect of baicalin on Marek's disease virus in CEF cells.

ABSTRACT:

Background

Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek's disease virus (MDV) activities of baicalin in CEF cells.

Results

Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in MDV infected CEFs.

Conclusions

These results demonstrate that baicalin could

SUBMITTER: Yang F 

PROVIDER: S-EPMC7532598 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature