Associations between gut microbiota and Alzheimer's disease, major depressive disorder, and schizophrenia.

ABSTRACT:

Background

Growing evidence has shown that alterations in the gut microbiota composition were associated with a variety of neuropsychiatric conditions. However, whether such associations reflect causality remains unknown. We aimed to reveal the causal relationships among gut microbiota, metabolites, and neuropsychiatric disorders including Alzheimer's disease (AD), major depressive disorder (MDD), and schizophrenia (SCZ).

Methods

A two-sample bi-directional Mendelian randomization analysis was performed by using genetic variants from genome-wide association studies as instrumental variables for gut microbiota, metabolites, AD, MDD, and SCZ, respectively.

Results

We found suggestive associations of host-genetic-driven increase in Blautia (OR, 0.88; 95%CI, 0.79-0.99; P

SUBMITTER: Zhuang Z 

PROVIDER: S-EPMC7532639 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature