Dataset Information

Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy.

ABSTRACT:

Background

Data on the long-term effects of prenatal exposure to maternal cancer and its treatment on child development are scarce.

Methods

In a multicenter cohort study, the neurologic and cardiac outcomes of 6-year-old children born to women diagnosed with cancer during pregnancy were compared with the outcome of children born after an uncomplicated pregnancy. Assessment included clinical evaluation, comprehensive neuropsychological testing, electrocardiography and echocardiography.

Results

In total, 132 study children and 132 controls were included. In the study group, 97 children (73.5%) were prenatally exposed to chemotherapy (alone or in combination with other treatments), 14 (10.6%) to radiotherapy (alone or in combination), 1 (0.8%) to trastuzumab, 12 (9.1%) to surgery alone and 16 (12.1%) to no treatment. Although within normal ranges, statistically significant differences were found in mean verbal IQ and visuospatial long-term memory, with lower scores in the study versus control group (98.1, 95% confidence interval [CI]: 94.5-101.8, versus 104.4, 95% CI: 100.4-108.4, P = 0.001, Q < 0.001 [Q refers to the false discovery rate adjusted P value], and 3.9, 95% CI: 3.6-4.3, versus 4.5, 95% CI: 4.1-4.9, P = 0.005, Q = 0.045, respectively). A significant difference in diastolic blood pressure was found, with higher values in chemotherapy-exposed (61.1, 95% CI: 59.0 to 63.2) versus control children (56.0, 95% CI 54.1 to 57.8) (P < 0.001, Q < 0.001) and in a subgroup of 59 anthracycline-exposed (61.8, 95% CI: 59.3 to 64.4) versus control children (55.9, 95% CI: 53.6 to 58.1) (P < 0.001, Q = 0.02).

Conclusions

Children prenatally exposed to maternal cancer and its treatment are at risk for lower verbal IQ and visuospatial long-term memory scores and for higher diastolic blood pressure, but other cognitive functions and cardiac outcomes were normal at the age of 6 years.

Clinical trial registration

The study is registered at ClinicalTrials.gov, NCT00330447.

SUBMITTER: Vandenbroucke T

PROVIDER: S-EPMC7532701 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy.

Vandenbroucke Tineke T Verheecke Magali M van Gerwen Mathilde M Van Calsteren Kristel K Halaska Michael J MJ Fumagalli Monica M Fruscio Robert R Gandhi Amarendra A Veening Margreet M Lagae Lieven L Ottevanger Petronella B PB Voigt Jens-Uwe JU de Haan Jorine J Gziri Mina M MM Maggen Charlotte C Mertens Luc L Naulaers Gunnar G Claes Laurence L Amant Frédéric F

European journal of cancer (Oxford, England : 1990) 20200825

<h4>Background</h4>Data on the long-term effects of prenatal exposure to maternal cancer and its treatment on child development are scarce.<h4>Methods</h4>In a multicenter cohort study, the neurologic and cardiac outcomes of 6-year-old children born to women diagnosed with cancer during pregnancy were compared with the outcome of children born after an uncomplicated pregnancy. Assessment included clinical evaluation, comprehensive neuropsychological testing, electrocardiography and echocardiogra ...[more]

PMID: 32858478

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Dataset Information

Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy.

Background

Methods

Results

Conclusions

Clinical trial registration

Publications

Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy.

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