Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy.

ABSTRACT:

Background

Data on the long-term effects of prenatal exposure to maternal cancer and its treatment on child development are scarce.

Methods

In a multicenter cohort study, the neurologic and cardiac outcomes of 6-year-old children born to women diagnosed with cancer during pregnancy were compared with the outcome of children born after an uncomplicated pregnancy. Assessment included clinical evaluation, comprehensive neuropsychological testing, electrocardiography and echocardiography.

Results

In total, 132 study children and 132 controls were included. In the study group, 97 children (73.5%) were prenatally exposed to chemotherapy (alone or in combination with other treatments), 14 (10.6%) to radiotherapy (alone or in combination), 1 (0.8%) to trastuzumab, 12 (9.1%) t

SUBMITTER: Vandenbroucke T 

PROVIDER: S-EPMC7532701 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature