Ontology highlight
ABSTRACT:
SUBMITTER: Kuzmin E
PROVIDER: S-EPMC7539174 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20200601 6498
Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mu ...[more]