Adjuvant treatment for high-risk salivary gland malignancies and prognostic stratification based on a 20-year single institution experience.

ABSTRACT:

Background and aim

Retrospective analysis of the utility of adjuvant radiation (RT) or chemoradiation (CRT) and identify prognostic features for patients with high-risk head and neck salivary gland cancers.

Methods

From 1/1997 to 12/2017, 108 patients underwent surgery, and RT (n = 50) or CRT (n = 58) for positive lymph node(s), extracapsular extension, perineural invasion, lymphovascular space invasion, positive/close margin, and/or grade 3 disease. Outcomes were estimated with the Kaplan-Meier method. Significant predictors identified through regression analyses were incorporated into multivariable regression (MVA). Toxicities were compared using chi-square.

Results

The median follow-up was 52 months (range: 3-226). The number of risk factors (RFs) between RT and CR

SUBMITTER: Onderdonk BE 

PROVIDER: S-EPMC7539565 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature