The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies.

ABSTRACT: The microbiome has been hypothesized to play a role in cancer development. Because of the diversity of published data, an overview of available epidemiologic evidence linking the microbiome with cancer is now needed. We conducted a systematic review using a tailored search strategy in Medline and EMBASE databases to identify and summarize the current epidemiologic literature on the relationship between the microbiome and different cancer outcomes published until December 2019. We identified 124 eligible articles. The large diversity of parameters used to describe microbial composition made it impossible to harmonize the different studies in a way that would allow meta-analysis, therefore only a qualitative description of results could be performed. Fifty studies reported differences in the

SUBMITTER: Huybrechts I 

PROVIDER: S-EPMC7541789 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature