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Stereoselective α-Tertiary Alkylation of N-(Arylacetyl)oxazolidinones.

ABSTRACT: A method has been developed for the α-tertiary alkylation of zirconium enolates of N-(arylacetyl)oxazolidinones. This reaction directly installs an all-carbon quaternary center vicinal to a benzylic tertiary carbon in a highly diastereoselective manner.

SUBMITTER: Shim E

PROVIDER: S-EPMC7544157 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Stereoselective α-Tertiary Alkylation of N-(Arylacetyl)oxazolidinones.

Shim Eunjae E Zakarian Armen A

Synlett : accounts and rapid communications in synthetic organic chemistry 20200401 7

A method has been developed for the α-tertiary alkylation of zirconium enolates of N-(arylacetyl)oxazolidinones. This reaction directly installs an all-carbon quaternary center vicinal to a benzylic tertiary carbon in a highly diastereoselective manner. ...[more]

PMID: 33041522

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