Skin CanceR Brachytherapy vs External beam radiation therapy (SCRiBE) meta-analysis.

ABSTRACT:

Background and purpose

To compare cosmesis and local recurrence (LR) of definitive external beam radiation therapy (EBRT) vs brachytherapy (BT) for indolent basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin.

Materials and methods

Studies including patients with T1-2 N0 SCCs/BCCs treated with definitive EBRT/BT and ≥10 months follow-up were analyzed. The primary endpoint was post-treatment cosmesis, categorized as "good," "fair," or "poor." The secondary endpoint was LR. Mixed effects regression models were used to estimate weighted linear relationships between biologically equivalent doses with α/β = 3 (BED₃) and cosmetic outcomes.

Results

A total of 9965 patients received EBRT and 553 received BT across 24 studies. Mean age was 73 ye

SUBMITTER: Zaorsky NG 

PROVIDER: S-EPMC7548033 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature