Alternative splicing of leptin receptor overlapping transcript in osteosarcoma.
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ABSTRACT: Impact statement
Osteosarcoma (OS, also known as osteogenic sarcoma) is the most common primary malignancy of bone in children and adolescents. The molecular mechanisms of OS are extremely complicated and its molecular mediators remain to be elucidated. We sequenced total RNA from 18 OS bone samples (paired normal-tumor biopsies). We found statistically significant (FDR <0.05) 26 differentially expressed transcript variants of LEPROT gene with different expressions in normal and tumor samples. These findings contribute to the understanding of molecular mechanisms of OS development and provide encouragement to pursue further research.
SUBMITTER: Rothzerg E
PROVIDER: S-EPMC7553092 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Alternative splicing of leptin receptor overlapping transcript in osteosarcoma.
Rothzerg Emel E Ho Xuan D XD Xu Jiake J Wood David D Märtson Aare A Maasalu Katre K Kõks Sulev S
Experimental biology and medicine (Maywood, N.J.) 20200812 16
<h4>Impact statement</h4>Osteosarcoma (OS, also known as osteogenic sarcoma) is the most common primary malignancy of bone in children and adolescents. The molecular mechanisms of OS are extremely complicated and its molecular mediators remain to be elucidated. We sequenced total RNA from 18 OS bone samples (paired normal-tumor biopsies). We found statistically significant (FDR <0.05) 26 differentially expressed transcript variants of <i>LEPROT</i> gene with different expressions in normal and t ...[more]
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