Ontology highlight
ABSTRACT:
SUBMITTER: De Luca A
PROVIDER: S-EPMC7555921 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200918 18
Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors involved in many biological processes. Deregulated FGFR signaling plays an important role in tumor development and progression in different cancer types. <i>FGFR</i> genomic alterations, including <i>FGFR</i> gene fusions that originate by chromosomal rearrangements, represent a promising therapeutic target. Next-generation-sequencing (NGS) approaches have significantly improved the discovery of <i>FGFR</i> gene fusions and ...[more]