3D Printed Gene-activated Octacalcium Phosphate Implants for Large Bone Defects Engineering.

ABSTRACT: The aim of the study was the development of three-dimensional (3D) printed gene-activated implants based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA. The first objective of the present work involved design and fabrication of gene-activated bone substitutes based on the OCP and plasmid DNA with VEGFA gene using 3D printing approach of ceramic constructs, providing the control of its architectonics compliance to the initial digital models. X-ray diffraction, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and compressive strength analyses were applied to investigate the chemical composition, microstructure, and mechanical properties of the experimental samples. The biodegradation rate and the efficacy of plasmid DNA delivery in

SUBMITTER: Bozo IY 

PROVIDER: S-EPMC7557339 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature