Clonal tracing reveals diverse patterns of response to immune checkpoint blockade.

ABSTRACT:

Background

Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple studies have sought to identify general biomarkers of ICB response, but elucidating the molecular and cellular drivers of resistance for individual tumors remains challenging. We sought to determine whether a tumor with defined genetic background exhibits a stereotypic or heterogeneous response to ICB treatment.

Results

We establish a unique mouse system that utilizes clonal tracing and mathematical modeling to monitor the growth of each cancer clone, as well as the bulk tumor, in response to ICB. We find that tumors derived from the same clonal populations showed heterogeneous ICB response and diverse response pa

SUBMITTER: Gu SS 

PROVIDER: S-EPMC7559192 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature