Alteration in topological properties of brain functional network after 2-year high altitude exposure: A panel study.

ABSTRACT:

Introduction

High altitude (HA) exposure leads to cognitive impairment while the underlying mechanism is still unclear. Brain functional network is crucial for advanced functions, and its alteration is implicated in cognitive decline in multiple diseases. The aim of current study was to investigate the topological changes in HA-exposed brain functional network.

Methods

Based on Shaanxi-Tibet immigrant cohort, neuropsychological tests and resting-state functional MRI were applied to evaluate the participants' cognitive function and functional connection (FC) changes, respectively. GRETNA toolbox was used to construct the brain functional network. The gray matter was parcellated into 116 anatomically defined regions according to Automated Anatomical Labeling atlas. Subsequentl

SUBMITTER: Xin Z 

PROVIDER: S-EPMC7559604 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature