Faecal microbiota transplantation as a home therapy to frail older people.

ABSTRACT:

Background

Clostridioides (Clostridium) difficile infection (CDI) is a leading cause of antibiotics-associated diarrhoea. Faecal microbiota transplantation (FMT) is effective for recurrent CDI and may be provided as a home treatment to frail, older people.

Methods

We present four consecutive patients with recurrent CDI, treated at home using nasojejunal tube-delivered or encapsulated donor faeces. The primary outcome was combined clinical resolution and a negative CD toxin test 8 weeks post-treatment.

Results

All four patients had severe CDI and all improved clinically following one FMT. Sustained resolution following one FMT was observed in one patient. Two patients had recurrence and received a second FMT using capsules; both achieved resolution. One patient who had

SUBMITTER: Jorgensen SMD 

PROVIDER: S-EPMC7583516 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature