Anemia and Incident End-Stage Kidney Disease.

ABSTRACT:

Background

Chronic kidney disease (CKD) progression can be a cause and potentially a consequence of anemia. Previous studies suggesting that anemia is associated with CKD progression have not utilized methodologic approaches to address time-dependent confounding.

Methods

We evaluated the association of anemia (defined using World Health Organization criteria of hemoglobin <12 g/dL in women and <13 g/dL in men) with incident ESRD and all-cause death in individuals with CKD using data from the Chronic Renal Insufficiency Cohort Study. Marginal structural models were used to account for time-dependent confounding.

Results

Among 3919 participants, 1859 (47.4%) had anemia at baseline. Over median follow up of 7.8 years, we observed 1,010 ESRD events and 994 deaths. In mult

SUBMITTER: Saraf SL 

PROVIDER: S-EPMC7591144 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature