Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis.

ABSTRACT: Differences in fentanyl pharmacokinetics (PK) between obese and nonobese adults have previously been reported; however, the impact of childhood obesity on fentanyl PK is relatively unknown. We developed a population pharmacokinetic (PopPK) model using opportunistically collected samples from a cohort of predominately obese children receiving fentanyl per the standard of care. Using a probability-based approach, we evaluated the ability of different continuous infusion strategies to provide steady-state concentrations (C_ss ) within an analgesic concentration range (1-3 ng/mL). Fifty-three samples from 32 children were used for PopPK model development. Median (range) age and body weight of study participants were 13 years (2-19 years) and 52 kg (16-164 kg), respectively. The major

SUBMITTER: Maharaj AR 

PROVIDER: S-EPMC7591270 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature