Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model.

ABSTRACT: The Akt family is comprised of three unique homologous proteins with isoform-specific effects, but isoform-specific in vivo data are limited in follicular thyroid cancer (FTC), a PI3 kinase-driven tumor. Prior studies demonstrated that PI3K/Akt signaling is important in thyroid hormone receptor β^PV/PV knock-in (PV) mice that develop metastatic thyroid cancer that most closely resembles FTC. To determine the roles of Akt isoforms in this model we crossed Akt1^-/-, Akt2^-/-, and Akt3^-/- mice with PV mice. Over 12 months, thyroid size was reduced for the Akt null crosses (p < 0.001). Thyroid cancer development and local invasion were delayed in only the PVPV-Akt1 knock out (KO) mice in association with increased apoptosis with no change in proliferati

SUBMITTER: Saji M 

PROVIDER: S-EPMC7591514 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature