Identification of driver genes and key pathways of non-functional pituitary adenomas predicts the therapeutic effect of STO-609.

ABSTRACT:

Objective

Our study is to identify DEGs (Differentially Expressed Genes), comprehensively investigate hub genes, annotate enrichment functions and key pathways of Non-functional pituitary adenomas (NFPAs), and also to verify STO-609 therapeutic effect.

Methods

The gene expression level of NFPA and normal tissues were compared to identify the DEGs (Differential expressed genes) based on gene expression profiles (GSE2175, GSE26966 and GSE51618). Enrichment functions, pathways and key genes were identified by carrying out GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis and PPI (Protein-Protein Interation) network analysis. Moreover, experiments in vitro were conducted to verify the anti-NFPAs effects of STO-609.

Results

169 over-expression gen

SUBMITTER: Wu B 

PROVIDER: S-EPMC7595405 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature