Does vancomycin administered at an empirical dose ensure coverage of pediatric patients against gram-positive pathogens?

ABSTRACT:

Objective

To investigate the vancomycin effectiveness against gram-positive pathogens with the minimum inhibitory concentration of 1mg/L in pediatric patients based on the area under the curve and the minimum inhibitory concentration ratio > 400.

Methods

A population of 22 pediatric patients (13 boys) admitted to the pediatric intensive care unit with preserved renal function was stratified in two groups (G1 < 7 years and G2 ≥ 7 years). After the fourth dose administered of vancomycin (10 - 15mg/kg every 6 hours) was administered, two blood samples were collected (third and fifth hours), followed by serum measurement by immunoassays to investigate the pharmacokinetics and antimicrobial coverage.

Results

There was no difference between the groups regarding dose, trough

SUBMITTER: Pires FR 

PROVIDER: S-EPMC7595722 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature