Assessment of Birth Defects and Cancer Risk in Children Conceived via In Vitro Fertilization in the US.

ABSTRACT:

Importance

Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF).

Objective

To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturally.

Design, setting, and participants

This cohort study of live births, birth defects, and cancer from Massachusetts, New York, North Carolina, and Texas included 1 000 639 children born to fertile women and 52 776 children conceived via IVF (using autologous oocytes and fresh embryos) during 2004-2016 in Massachusetts and North Carolina, 2004-2015 in New York, and 2004-2013 in Texas. Children were followed up for an average of 5.

SUBMITTER: Luke B 

PROVIDER: S-EPMC7596575 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature