Ontology highlight
ABSTRACT:
SUBMITTER: Renner H
PROVIDER: S-EPMC7609049 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
eLife 20201103
Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS). However, current protocols yield either complex but highly heterogeneous aggregates ('organoids') or 3D structures with less physiological relevance ('spheroids'). Here, we present a scalable, HTS-compatible workflow for the automated generation, maintenance, and optical analysis of human midbrain organoids in standard 96-well-plates. The res ...[more]