Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion.

ABSTRACT:

Purpose

We previously demonstrated that sex influences response to immune checkpoint inhibitors. In this article, we investigate sex-based differences in the molecular mechanisms of anticancer immune response and immune evasion in patients with NSCLC.

Experimental design

We analyzed (i) transcriptome data of 2,575 early-stage NSCLCs from seven different datasets; (ii) 327 tumor samples extensively characterized at the molecular level from the TRACERx lung study; (iii) two independent cohorts of 329 and 391 patients, respectively, with advanced NSCLC treated with anti-PD-1/anti-PD-L1 drugs.

Results

As compared with men, the tumor microenvironment (TME) of women was significantly enriched for a number of innate and adaptive immune cell types, including specific T-cell s

SUBMITTER: Conforti F 

PROVIDER: S-EPMC7611463 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature