Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients.

ABSTRACT: Hyperpolarized ¹³C-MRI is an emerging tool for probing tissue metabolism by measuring ¹³C-label exchange between intravenously injected hyperpolarized [1-¹³C]pyruvate and endogenous tissue lactate. Here, we demonstrate that hyperpolarized ¹³C-MRI can be used to detect early response to neoadjuvant therapy in breast cancer. Seven patients underwent multiparametric ¹H-MRI and hyperpolarized ¹³C-MRI before and 7-11 days after commencing treatment. An increase in the lactate-to-pyruvate ratio of approximately 20% identified three patients who, following 5-6 cycles of treatment, showed pathological complete response. This ratio correlated with gene expression of the pyruvate transporter MCT1 and lactate dehydrogenase A (

SUBMITTER: Woitek R 

PROVIDER: S-EPMC7612070 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature