Imaging breast cancer using hyperpolarized carbon-13 MRI.

ABSTRACT: Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using ¹³C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized ¹³C label exchange between injected [1-¹³C]pyruvate and the endogenous tumor lactate pool. Treatment-naïve breast cancer patients were recruited: four triple-negative grade 3 cancers; two invasive ductal carcinomas that were estrogen and progesterone receptor-positive (ER/PR+) and HER2/neu-negative (HER2-), one grade 2 and one grade 3; and one grade 2 ER/PR+ HER2- invasive lobular carcinoma (ILC). Dynamic ¹³C MRSI was performed following injection of hyperpolarized [1-¹³C]pyruvate. Expression of lactate dehydrogenase A (LDHA), which catalyzes ¹³C label

SUBMITTER: Gallagher FA 

PROVIDER: S-EPMC6995024 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature