TDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel.

ABSTRACT:

Background and objective

Transcranial direct current stimulation (tDCS) has wide ranging applications in neuro-behavioural and physiological research, and in neurological rehabilitation. However, it is currently limited by substantial inter-subject variability in responses, which may be explained, at least in part, by anatomical differences that lead to variability in the electric field (E-field) induced in the cortex. Here, we tested whether the variability in the E-field in the stimulated cortex during anodal tDCS, estimated using computational simulations, explains the variability in tDCS induced changes in GABA, a neurophysiological marker of stimulation effect.

Methods

Data from five previously conducted MRS studies were combined. The anode was placed over the left prim

SUBMITTER: Nandi T 

PROVIDER: S-EPMC7613675 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature