Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease.

ABSTRACT: Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in humans, we characterized the colonic γδ T cell compartment, identifying a diverse repertoire that includes a phenotypically distinct subset coexpressing T cell receptor Vγ4 and the epithelium-binding integrin CD103. This subset was disproportionately diminished and dysregulated in inflammatory bowel disease, whereas on-treatment CD103⁺γδ T cell restoration was associated with sustained inflammatory bowel disease remission. Moreover, CD103⁺Vγ4⁺cell dysregulation and loss were also displayed by humans with germline BTNL3/BTNL8 hypomorphism, which we identified as a risk factor

SUBMITTER: Dart RJ 

PROVIDER: S-EPMC7615126 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature