Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

ABSTRACT: A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.

Introduction

The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD).

Methods

We studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19.5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Cova

SUBMITTER: Kanis JA 

PROVIDER: S-EPMC7615305 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature