Ontology highlight
ABSTRACT:
SUBMITTER: Zhu K
PROVIDER: S-EPMC7615817 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Zhu Kang K Suskiewicz Marcin J MJ Hloušek-Kasun Andrea A Meudal Hervé H Mikoč Andreja A Aucagne Vincent V Ahel Dragana D Ahel Ivan I
Science advances 20221005 40
Ubiquitylation had been considered limited to protein lysine residues, but other substrates have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3' hydroxyl of the adenosine diphosphate (ADP)-ribosyl moiety that can be linked to a protein, thus generating a hybrid ADP-ribosyl-ubiquitin modification. Unlike other known hydroxyl-specific E3s, which proceed via a covalent E3~ubiqutin intermediate, DELTEX enzymes are RING E3s that stimulate a direct ubiquitin transfer ...[more]