Ontology highlight
ABSTRACT:
SUBMITTER: Ebrahimighaei R
PROVIDER: S-EPMC7616274 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Ebrahimighaei Reza R Sala-Newby Graciela B GB Hudson Claire C Kimura Tomomi E TE Hathway Tom T Hawkins Joseph J McNeill Madeleine C MC Richardson Rebecca R Newby Andrew C AC Bond Mark M
Biochimica et biophysica acta. Molecular cell research 20220726 11
Cardiac fibrosis is associated with increased stiffness of the myocardial extracellular matrix (ECM) in part mediated by increased cardiac fibroblast proliferation However, our understanding of the mechanisms regulating cardiac fibroblast proliferation are incomplete. Here we characterise a novel mechanism involving a combined activation of Yes-associated protein (YAP) targets RUNX Family Transcription Factor 2 (RUNX2) and TEA Domain Transcription Factor (TEAD). We demonstrate that cardiac fibro ...[more]