A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest.

ABSTRACT:

Background

In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug administration than an intravenous route; however, its effect on clinical outcomes is uncertain.

Methods

We conducted a multicenter, open-label, randomized trial across 11 emergency medical systems in the United Kingdom that involved adults in cardiac arrest for whom vascular access for drug administration was needed. Patients were randomly assigned to receive treatment from paramedics by means of an intraosseous-first or intravenous-first vascular access strategy. The primary outcome was survival at 30 days. Key secondary outcomes included any return of spontaneous circula

SUBMITTER: Couper K 

PROVIDER: S-EPMC7616768 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature