Associations of schizophrenia with arrhythmic disorders and electrocardiogram traits: genetic exploration of population samples.

ABSTRACT:

Background

An important contributor to the decreased life expectancy of individuals with schizophrenia is sudden cardiac death. Arrhythmic disorders may play an important role herein, but the nature of the relationship between schizophrenia and arrhythmia is unclear.

Aims

To assess shared genetic liability and potential causal effects between schizophrenia and arrhythmic disorders and electrocardiogram (ECG) traits.

Method

We leveraged summary-level data of large-scale genome-wide association studies of schizophrenia (53 386 cases, 77 258 controls), arrhythmic disorders (atrial fibrillation, 55 114 cases, 482 295 controls; Brugada syndrome, 2820 cases, 10 001 controls) and ECG traits (heart rate (variability), PR interval, QT interval, JT interval and QRS duration,

SUBMITTER: Treur JL 

PROVIDER: S-EPMC7616879 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature