Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.

ABSTRACT:

Objectives

Observational studies report mixed findings regarding the association between vitamin D and juvenile idiopathic arthritis (JIA) incidence or activity; however, such studies are susceptible to considerable bias. Because low vitamin D levels are common within the general population and easily corrected, there is potential public health benefit in identifying a causal association between vitamin D insufficiency and JIA incidence. To limit bias due to confounding and reverse causation, we examined the causal effect of the major circulating form of vitamin D, 25-hydroxy vitamin D (25-[OH]D), on JIA incidence using Mendelian randomization (MR).

Methods

In this 2-sample MR analysis, we used summary level data from the largest and most recent genome-wide association study

SUBMITTER: Clarke SLN 

PROVIDER: S-EPMC7617134 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature