Adeno-associated virus 2 infection in children with non-A-E hepatitis.

ABSTRACT: An outbreak of acute hepatitis of unknown aetiology in children was reported in Scotland¹ in April 2022 and has now been identified in 35 countries². Several recent studies have suggested an association with human adenovirus with this outbreak, a virus not commonly associated with hepatitis. Here we report a detailed case-control investigation and find an association between adeno-associated virus 2 (AAV2) infection and host genetics in disease susceptibility. Using next-generation sequencing, PCR with reverse transcription, serology and in situ hybridization, we detected recent infection with AAV2 in plasma and liver samples in 26 out of 32 (81%) cases of hepatitis compared with 5 out of 74 (7%) of samples from unaffected individuals. Furthermore, AAV2 was detected w

SUBMITTER: Ho A 

PROVIDER: S-EPMC7617659 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature