Dataset Information

Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants.

ABSTRACT:

Introduction

Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors.

Methods

In UK Biobank, a population cohort study, baseline data were linked to COVID-19 deaths. Poisson regression was used to study the association between current age and COVID-19 mortality.

Results

Among eligible participants, 438 (0.09%) died of COVID-19. Current age was associated exponentially with COVID-19 mortality. Overall, participants aged ≥75 years were at 13-fold (95% CI 9.13-17.85) mortality risk compared with those <65 years. Low forced expiratory volume in 1 second, high systolic blood pressure, low handgrip strength, and multiple long-term conditions were significant mediators, and collectively explained 39.3% of their excess risk. The associations between these risk factors and COVID-19 mortality were stronger among older participants. Participants aged ≥75 without additional risk factors were at 4-fold risk (95% CI 1.57-9.96, P = 0.004) compared with all participants aged <65 years.

Conclusions

Higher COVID-19 mortality among older adults was partially explained by other risk factors. 'Healthy' older adults were at much lower risk. Nonetheless, older age was an independent risk factor for COVID-19 mortality.

SUBMITTER: Ho FK

PROVIDER: S-EPMC7644030 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants.

Ho Frederick K FK Petermann-Rocha Fanny F Gray Stuart R SR Jani Bhautesh D BD Katikireddi S Vittal SV Niedzwiedz Claire L CL Foster Hamish H Hastie Claire E CE Mackay Daniel F DF Gill Jason M R JMR O'Donnell Catherine C Welsh Paul P Mair Frances F Sattar Naveed N Celis-Morales Carlos A CA Pell Jill P JP

PloS one 20201105 11

<h4>Introduction</h4>Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors.<h4>Methods</h4>In UK Biobank, a population cohort study, baseline data were linked to COVID-19 deaths. Poisson regression was used to study the association between current age and COVID-19 mortality.<h4>Results</h4>Among eligible participa ...[more]

PMID: 33152008

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Dataset Information

Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants.

Introduction

Methods

Results

Conclusions

Publications

Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants.

Similar Datasets

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