Ontology highlight
ABSTRACT:
SUBMITTER: Koudelka T
PROVIDER: S-EPMC7645863 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Koudelka Tomas T Boger Juliane J Henkel Alessandra A Schönherr Robert R Krantz Stefanie S Fuchs Sabine S Rodríguez Estefanía E Redecke Lars L Tholey Andreas A
Proteomics 20201117 2
The genome of coronaviruses, including SARS-CoV-2, encodes for two proteases, a papain like (PL<sup>pro</sup> ) protease and the so-called main protease (M<sup>pro</sup> ), a chymotrypsin-like cysteine protease, also named 3CL<sup>pro</sup> or non-structural protein 5 (nsp5). M<sup>pro</sup> is activated by autoproteolysis and is the main protease responsible for cutting the viral polyprotein into functional units. Aside from this, it is described that M<sup>pro</sup> proteases are also capable ...[more]