Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients.

ABSTRACT: A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity has come out as a determinant for COVID-19 clinical outcomes, and several studies investigated the immune profiling of SARS-CoV-2 infected people to properly direct the clinical management of the disease. Thus, lymphopenia, T-cell exhaustion, and the increased levels of inflammatory mediators have been described in COVID-19 patients, in particular in severe cases¹. Age represents a key factor in COVID-19 morbidity and mortality². Understanding age-associated immune signatures of patients are therefore important to identify preventive and therapeutic strategies. In this study, we investigated the immune profile of COVID-19 hospitalized patients identifying a distinctive age-depende

SUBMITTER: Angioni R 

PROVIDER: S-EPMC7646225 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature