ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer is one of the most common cancers in the word. However, the underlying mechanism remains largely unknown. ACOT11 encodes enzymes hydrolyzing the fatty acyl-CoA esters into free fatty acids and CoA. Besides from its role in fatty acid metabolism, the other aspects regarding its function in the progression of lung cancer have not been revealed.

Methods

We first explored the clinical profile of ACOT11 in tumor samples. Next, we combined gene knockdown in vitro and in vivo and microarray gene profiling analysis to decipher the unknown regulatory role of ACOT11 in lung cancer carcinoma. Furthermore, we explored the potential molecular mechanisms of ACOT11 with immunoprecipitation.

Results

We found high expres

SUBMITTER: Liang C 

PROVIDER: S-EPMC7653140 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature