Ontology highlight
ABSTRACT:
SUBMITTER: Mapperley C
PROVIDER: S-EPMC7653684 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Mapperley Christopher C van de Lagemaat Louie N LN Lawson Hannah H Tavosanis Andrea A Paris Jasmin J Campos Joana J Wotherspoon David D Durko Jozef J Sarapuu Annika A Choe Junho J Ivanova Ivayla I Krause Daniela S DS von Kriegsheim Alex A Much Christian C Morgan Marcos M Gregory Richard I RI Mead Adam J AJ O'Carroll Dónal D Kranc Kamil R KR
The Journal of experimental medicine 20210301 3
The mRNA N6-methyladenosine (m6A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m6A mRNA reader YTHDF2, which recognizes m6A-modified transcripts to promote m6A-mRNA degradation, results in hematopoietic stem cell (HSC) expansion and compromises acute myeloid leukemia. Here we investigate the long-term impact of YTHDF2 deletion on HSC maintenance and multilineage hematopoiesis. We demonstrate that Ythdf2-deficient HSCs from young mi ...[more]