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Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures.

ABSTRACT: Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis, illness treatment, biomechanics, bio-optics and bio-electronics, etc. This review outlines recent efforts directed to the creation of structurally defined protein assemblies including one-dimensional (1D) strings/rings/tubules, two-dimensional (2D) planar sheets and three-dimensional (3D) polyhedral scaffolds. We elucidate various innovative strategies for manipulating proteins to self-assemble into desired architectures. The emergent applications of protein assemblies as versatile platforms in medicine and material science with improved performances have also been discussed.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC7658299 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures.

Zhang Wenbo W   Mo Shanshan S   Liu Mingwei M   Liu Lei L   Yu Lanlan L   Wang Chenxuan C  

Frontiers in chemistry 20201029

Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis, illness treatment, biomechanics, bio-optics and bio-electronics, etc. This review outlines recent efforts directed to the creation of structurally defined protein assemblies including one-dimensional  ...[more]