Risk Stratification of Prostate Cancer Through Quantitative Assessment of PTEN Loss (qPTEN).

ABSTRACT:

Background

Phosphatase and tensin homolog (PTEN) loss has long been associated with adverse findings in early prostate cancer. Studies to date have yet to employ quantitative methods (qPTEN) for measuring of prognostically relevant amounts of PTEN loss in postsurgical settings and demonstrate its clinical application.

Methods

PTEN protein levels were measured by immunohistochemistry in radical prostatectomy samples from training (n = 410) and validation (n = 272) cohorts. PTEN loss was quantified per cancer cell and per tissue microarray core. Thresholds for identifying clinically relevant PTEN loss were determined using log-rank statistics in the training cohort. Univariate (Kaplan-Meier) and multivariate (Cox proportional hazards) analyses on various subpopulations were pe

SUBMITTER: Jamaspishvili T 

PROVIDER: S-EPMC7669224 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature