Ontology highlight
ABSTRACT:
SUBMITTER: Helmsauer K
PROVIDER: S-EPMC7669906 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201116 1
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA). The exact amplicon structure has not been described thus far and the functional relevance of its rearrangements is unknown. Here, we analyze the MYCN amplicon structure using short-read and Nanopore sequencing and its chromatin landscape using ChIP-seq, ATAC-seq and Hi-C. This reveals two distinct classes of amplicons which exp ...[more]