Forced Expiratory Flow (FEF_25-75%) as a Clinical Endpoint in Children and Adolescents with Symptomatic Asthma Receiving Tiotropium: A Post Hoc Analysis.

ABSTRACT:

Introduction

In pediatric patients with asthma, measurements of forced expiratory volume in 1 s (FEV₁) may be normal or may not correlate with symptom severity. Forced expiratory flow at 25-75% of the vital capacity (FEF_25-75%) is a potentially more sensitive parameter for assessing peripheral airway function. This post hoc analysis compared FEF_25-75% with FEV₁ as an endpoint to assess bronchodilator responsiveness in children with asthma.

Methods

Change from baseline in trough FEF_25-75% and trough FEV₁ following treatment with either tiotropium (5 µg or 2.5 µg) or placebo Respimat^® was analyzed in four phase III trials in children (aged 6-11 years) and adolescents (aged 12-17 years) with symptomati

SUBMITTER: Szefler SJ 

PROVIDER: S-EPMC7672130 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature