Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection.

ABSTRACT: Antibodies against viral pathogens represent promising therapeutic agents for the control of infection, and their antiviral efficacy has been shown to require the coordinated function of both the Fab and Fc domains¹. The Fc domain engages a wide spectrum of receptors on discrete cells of the immune system to trigger the clearance of viruses and subsequent killing of infected cells^1-4. Here we report that Fc engineering of anti-influenza IgG monoclonal antibodies for selective binding to the activating Fcγ receptor FcγRIIa results in enhanced ability to prevent or treat lethal viral respiratory infection in mice, with increased maturation of dendritic cells and the induction of protective CD8⁺ T cell responses. These findings highlight the capacity for IgG a

SUBMITTER: Bournazos S 

PROVIDER: S-EPMC7672690 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature