Detection of cellular micromotion by advanced signal processing.
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ABSTRACT:
SUBMITTER: Rinner S
PROVIDER: S-EPMC7675976 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Detection of cellular micromotion by advanced signal processing.
Rinner Stephan S Trentino Alberto A Url Heike H Burger Florian F von Lautz Julian J Wolfrum Bernhard B Reinhard Friedemann F
Scientific reports 20201118 1
Cellular micromotion-a tiny movement of cell membranes on the nm-µm scale-has been proposed as a pathway for inter-cellular signal transduction and as a label-free proxy signal to neural activity. Here we harness several recent approaches of signal processing to detect such micromotion in video recordings of unlabeled cells. Our survey includes spectral filtering of the video signal, matched filtering, as well as 1D and 3D convolutional neural networks acting on pixel-wise time-domain data and a ...[more]
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