Ontology highlight
ABSTRACT:
SUBMITTER: Di Francesco A
PROVIDER: S-EPMC7678866 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
NPJ aging and mechanisms of disease 20201119 1
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-induced metabolic defects through preservation of glucose homeostasis, insulin sensitivity, and lipid handling with improved physiological outcomes. NQO1-RNA interaction mediated the association with ...[more]