Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders.

ABSTRACT:

Background

Accumulating reports have suggested that α-synuclein is involved in the pathogenesis of Alzheimer's disease (AD). As the cerebrospinal fluid (CSF) α-synuclein has been suggested as a potential biomarker of AD, this study was set out to test whether CSF α-synuclein is associated with other AD biomarkers and could predict neurodegeneration and clinical progression in non-demented elders.

Methods

The associations between CSF α-synuclein and other AD biomarkers were investigated at baseline in non-demented Chinese elders. The predictive values of CSF α-synuclein for longitudinal neuroimaging change and the conversion risk of non-demented elders were assessed using linear mixed effects models and multivariate Cox proportional hazard models, respectively, in the Alzheim

SUBMITTER: Li JQ 

PROVIDER: S-EPMC7685645 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature